Changes of Plasma uPA and TGF-β1 in Patients with Preeclampsia
Abstract
Objective To investigate the roles of uPA and TGF-β1 in the etiology of preeclampsia (PE). Methods The plasma uPA and TGF-β1 were determined with enzyme linked immunosorbent assay (ELISA) in 133 patients with PE (74 patients with mild PE and 59 with severe PE), and compared with those with normal pregnancy (n=141). Results The patients with PE had lower levels of plasma uPA (456.19±37.47) pg/ml than those with normal pregnancy [(676.24±47.16) pg/ml, P<0.01] with statistical significance. No significant difference was found in levels of plasma uPA between the patients with severe PE (437.24±47.32) pg/ml and the patients with mild PE [(478.13±15.89) pg/ml, P>0.05]. The patients with PE had higher levels of plasma TGF-β1 (16.28±5. 62) ng/ml than that of normal pregnancy [(8.96±3.61) ng/ml, P<0.05]. No significant difference was found in the levels of plasma TGF-β1 between patients with severe PE (14.83±5.02) ng/ml and patients with mild PE [(12. 89±2.61) ng/ml, P>0.05]. There was a negative correlation between plasma uPA and TGF-β1 in patients with PE (P<0.01). Conclusion The changes of uPA and TGF-β1 are associated with the pathogenesis and development of PE.
Keywords
Preeclampsia; uPA; TGF-β1; Plasma
Publication Date
DOI
10.12783/dtssehs/isetem2016/4387
10.12783/dtssehs/isetem2016/4387