Research Progress on the Correlation Between SLE and Malignant Tumor

Abstract

Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease, characterized by a wide array of symptoms and organ involvements, leading to varying disease courses and outcome, and ranging from mild to severe types. In patients with SLE, the incidence and risk of malignancy development is increased, and non-Hodgkin's lymphoma (NHL), cervical cancer, as well as bronchial carcinomas occur, are common malignancy types.
Common genetic predisposition, chronic antigen stimulus, disproportional immune responses, as well as the chronic administration of immunosuppressive medications can contribute to the development of malignancies in SLE patients. In this review we present some research areas such as the molecular pathology, epidemiological and clinical of the malignancies in SLE patients population.