Correlation Between Serum Estradiol and Lung Cancer in Chinese Population

Abstract

To analyze the correlation between the serum estradiol and lung cancer in Chinese population, PubMed, the Cochrane database and the China National Knowledge Internet database as well as VIP, WANGFANG MED, Sino Med were comprehensively searched for related studies strictly according to the selection criteria. Statistical analysis was performed using Review Manager 5.3 software. 16 studies were included for analysis, of which there were 736 subjects in the lung cancer group, 544 ones in the healthy control group. The results of
Meta-analysis showed that the serum estradiol levels were higher in the lung cancer group than in the control one (SMD=0.81, 95%CI 0.31-1.30, Z=3.20, P<0.01). Meanwhile, from the subgroup analysis, the level of serum estradiol was higher in male lung cancer group (SMD=0.62, 95%CI 0.03-1.21, Z=2.06, P<0.05), but not in the female lung cancer group (SMD=0.02, 95%CI -0.51-0.55, Z=0.06, P>0.05) compared to the healthy control groups. Therefore, the serum estradiol level in the patients with lung cancer is higher than that in the
healthy control population, suggesting serum estradiol level may be associated with the pathogenesis of lung cancer and expected to become a marker for the diagnosis of lung cancer, especially in Chinese population.