The Establishment and Evaluation of an Optimal Sensitizing System Induced Via Houttuynia Cordata Injection

Abstract

Evaluation of potential reaction prior to administration of drugs is important to avoid an adverse reaction. Animal models are necessary for this process. In this study, we compared the difference between Sprague Dawley (SD) rat and rhesus monkey in response to Houttuynia cordata injection to evaluate this process. We found that the allergic reaction of the rhesus monkey was much stronger at a low dose (7.2 mg/kg) as compared with the SD rat. The IgE and histamine were significantly increased in the Houttuynia cordata injection groups, as were the expressions of IFN-γ, IL-4, IL-10 and IL-13 in the Houttuynia cordata distillation groups, but all these factors did not result in changes in the SD rat. These findings indicate that the rhesus monkeys may be a better choice for testing drug allergic reaction using the Houttuynia Cordata injection process.