The Preparation of Core–shell Structured Gelatin–chitosan Nanofibers for Biomedical Applications

Abstract

In recently, electrospun nature fibers have been investigated as scaffolding materials for tissue engineering. In this study, The core-shell structured of nanofibers were prepared by coaxial electrospinning, where the natural polymer chitosan(CS) as shell and the highly spinnable gelatin(GEL) was used as core. In order to maintain the structure of the nanofibers that kept them in contact with aqueous medium. In this report, we used glutaraldehyde as the cross-linking agent for improving the water stability of the nanofibers. The results show that the as prepared core-shell structure and the cross-linked nanofibers exhibits better water stability.