Noninvasive Determine Lead Poisoning Biomarker for Human Body—Design and Manufacture on Innovated New-XRF Analyzer of Bone Lead

Abstract

This research introduces an important noninvasive technique which is In vivo measurement of human body bone lead. It makes use of the miniature X tube emitting X-ray through sebum to stimulate the characteristic X fluorescence at the position of tibia under its surface about 1 ～ 1.5 mms. The characteristic X fluorescence which express bone lead content and asking for help from Si-PIN detector and M.C.A analysis system to output a bone lead density d. This technique use the relative functions between sebum thick t and spectrum- unfolding area for bone lead peak. The Compton scatter integral value C could represent sebum thick. It will be calculated the lead content of tibia with ppm .The experiment of this instrument measured 52 data gained by volunteers. This measurement results with other measuring results by international researches are mutually fits together. Thus it is credible that the N-XRF instrument can be possible in vivo to measure bone lead in human body.