The Effect of the Ratio of Total Flavonoids and Total Saponins of Mao Dongqing on TIA Model Mice

Abstract

To study the effect of the different components of the total flavonoids and total saponins from the active part of Mao Dongqing on the TIA model of mice, and screen out the optimal proportion of the active components in the control of TIA. Method: The TIA model was established by tail vein injection of tert butyl alcohol in mice, and the content of MDA, LD, SOD, LDH activity and the changes of brain tissue were determined. Result: Total flavonoids and total saponins of Mao Dongqing active site of 10:5, 10:6 And 10:7 ratio was high and middle dose group could significantly improve the pathological injury of brain tissue of mice, significantly decreased MDA and LD content in brain tissue of mice, significantly increased SOD and LDH activity in brain of mice with 10:6, total flavonoids and total saponins of Mao Dongqing optimal active ratio components.Conclusion:10:6 for the prevention and control of total flavonoids and total saponins of Mao Dongqing TIA optimal activity ratio of components. Mao Dongqing is commonly used in traditional Chinese medicine, promoting blood circulation and relieving pain, detoxification of reactive power, the coronary heart disease, acute myocardial infarction, thromboangiitis obliterans, curative effect is better, Also reports hairy Holly can improve the blood supply of the organization, is conducive to ischemia partial recovery, clinically used in the treatment of ischemic stroke[1]. Previous studies have shown that Mao Dongqing has good anti cerebral ischemia effect, Mao Dongqing's total flavonoids and total saponins are the main active part of Mao Dongqing's anti cerebral ischemia, and also the main component of the body of Mao Dongqing. In order to study the characteristics of Mao Dongqing's anti cerebral ischemia, the effects of different ratios of total flavonoids and total saponins of on TIA mice were observed.