Effect of Polyethylene Oxide Concentration on Blood Compatibility of PVDF Hollow Fiber Plasma Separation Membranes

Abstract

The anticoagulant properties of commonly PES/PVP plasma separation modified membrane materials are not ideal enough. Based on that, in this paper, a newly developed plasma separator made of polyvinylidene fluoride (PVDF) hollow fiber membranes was prepared by dry/wet phase inversion method with blended hydrophilic macromolecular polyethylene oxide (PEO). The effect of PEO concentration was evaluated for its blood compatibility. The results showed that the anticoagulant properties of PVDF/PEO modified membrane were more excellent than the PES/PVP modified membrane. And attenuated total reflection flourier transformed infrared spectroscopy (ATR-FTIR) analysis confirmed that the PEO macromolecular additives remained within the PVDF modified membrane, which could effectively improve hydrophilicity of the membrane.